|Is there A Difference in the Neuropsychological Profile of HIV-infected Patients on Protease Inhibitor Monotherapy vs Triple Therapy?|| |
|A. González-Baeza1, C. Bayón1, I. Pérez-Valero1, M. Estébanez1, J.I. Bernardino1, S. Monge1, M. Lagarde2, F. Pulido2, F.X. Zamora1, M.L. Montes1, J.J. González-García1, J.R. Arribas1|
|1La Paz University Hospital, IdiPAZ, Madrid, Spain, 2Hospital 12 de Octubre, Madrid, Spain|
|Objectives: To compare cognitive domains function in HIV-infected patients treated with protease inhibitor monotherapy or triple therapy.|
Methods: In this cross-sectional study we included patients without concomitant major neurocognitive confounders, who were currently receiving boosted lopinavir or darunavir as monotherapy (n=95) or as triple therapy (n=96) and had suppressed plasma viral load (< 50 copies/ml) for at least one year. Patients underwent a neuropsychological (NP) test battery, covering 7 domains. After adjustment, inter-group differences in test average scores and rate of deficits were analyzed in all NP measures.
Results: Both groups showed a similar general neurocognitive pattern. However, patients on monotherapy showed better verbal learning (p= 0.02; d= 0.28) and verbal recall (p< 0.01; d= 0.12) scores, while patients on triple therapy performed slightly better in motor skills with dominant hand (p= 0.02; d= 0.23) (table 1). There were no differences between groups in the proportion of patients with mild deficit (>-2SDs ≤-1SDs). Patients on triple therapy showed higher proportions of moderate deficit (≤ -2SD) in the Trail Making Test form A (monotherapy 0%,triple therapy 5.3%; p= 0.03) and form B (monotherapy 0% ,triple therapy 5.3%; p= 0.03).
Conclusions: Although we found some differences in verbal memory and motor measures patients receiving effective protease inhibitor monotherapy had, overall, a similar NP pattern than patients receiving triple therapy.
Mean (standard deviation)||Monotherapy
Mean (standard deviation)||Effect Size
(Cohen's d)||p value
|Verbal learning||54.3 (8.7)||56.9 (10.5)||0.28||0.06||3.51||0.02|
|Verbal recall||43.3 (10.6)||46.2 (11.9)||0.25||0.08||4.91||<0.01|
|Motor skill- dominan hand||47.2 (13.7)||44.1 (14.0)||0.23||0.12||-4.68||0.02|
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Adjustment variables included were: treatment, years on ART, triglycerides, marihuana use, type of PI prescribed, vocabulary score, nadir CD4 count, HOMA index and vocabulary test score.
NEUROPSYCHOLOGIST Alicia González-Baeza , La Paz University Hospital, IdiPAZ , Madrid , Spain
Assigned in sessions:
17.10.2013, 12:00-14:00, Poster Session, Poster Session 1, Exhibition
18.10.2013, 12:00-14:00, Poster Session, Poster Session 2, Exhibition