Abstract PS5.3
Dietary patterns not associated with the risk of multiple sclerosis Print
DL Rotstein1, S Chiuve2, T Chitnis1, T Fung2, KL Munger2
1Brigham and Women's Hospital, Harvard Medical School, Neurology, Boston, MA, United States, 2Harvard School of Public Health, Boston, MA, United States
Background: With the exception of vitamin D, previous studies on diet and multiple sclerosis (MS) risk have yielded null or inconsistent results.
Objectives: To determine whether there is any association between measures of overall diet quality (dietary indices/patterns) and the risk of MS. These measures have been associated with reduced risks of other chronic diseases, including cardio- and cerebrovascular disease, dementia, and diabetes.
Methods: Over 185,000 women in the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII) completed semi-quantitative food frequency questionnaires (FFQ) every 4 years beginning in 1984 (NHS) or 1991 (NHSII). There were 480 incident cases of MS identified and validated between baseline and 2004 (NHS) or 2009 (NHSII). Scores on the Alternative Healthy Eating Index-2010 (AHEI-2010), Alternate Mediterranean Diet (aMED) index, and Dietary Approaches to Stop Hypertension (DASH) index were calculated from the FFQs. Principal components analysis was used to derive major dietary patterns. Using a Cox proportional hazards model, we calculated the relative risk (RR) of MS and 95% confidence intervals. Multivariate analyses were adjusted for age, latitude of residence at age 15, ethnicity, body mass index at age 18, supplemental vitamin D intake, and cigarette smoking.
Results: None of the dietary indices, AHEI-2010, aMED, or DASH, at baseline were statistically significantly related to the risk of MS. Specifically, the multivariate-adjusted pooled RR of MS comparing the highest to lowest quintile was 0.89 (p for trend=0.77) for the AHEI-2010, 1.10 (p=0.19) for aMED, and 1.30 (p=0.23) for DASH. The principle components analysis identified two dietary patterns, “western” and “prudent”, neither of which was associated with MS risk (western, top vs. bottom quintile RR=0.71 (p=0.1) for, and prudent, 1.09 (p=0.57). When the analysis was repeated using the cumulative average dietary pattern scores, the results were likewise null.
Conclusions: This is the first large, prospective, population-based study to investigate whether overall diet quality may contribute to the development of MS, and no evidence for such an association was found.

Assigned speakers:
M.D. Dalia Rotstein , Brigham and Women's Hospital, Harvard Medical School , Boston , US

Assigned in sessions:
11.09.2014, 14:00-15:30, Parallel sessions, PS5, Comorbidities and risk behaviors (PS5.1-PS5.6), Grand Ballroom